Farm Chemicals
Setting aside herbicides, the primary lethal threats to agricultural workers and local ecosystems from historical cotton farming come from systemic insecticides—specifically Aldicarb and Endosulfan. Because of their extreme toxicity, both have generated extensive restricted-use field reports, Environmental Protection Agency (EPA) cancellation orders, and international bans.
Here is the documented harm caused by these chemicals:
Aldicarb (Carbamate Insecticide / Nematicide)
Farmworker Harm: Aldicarb is one of the most acutely toxic pesticides ever registered. It acts as a severe cholinesterase inhibitor. Field reports document that farmworkers exposed through skin contact or inhalation during application suffer rapid nervous system overload, resulting in blurred vision, violent muscle spasms, pulmonary edema (fluid in the lungs), and death by respiratory paralysis.
Animal & Ecosystem Harm: Aldicarb is notoriously lethal to wildlife. Granular applications left on the soil surface have caused massive avian die-offs; EPA field reports note that a single ingested granule is enough to kill a songbird. Furthermore, it is highly mobile in soil. In the late 1970s and 1980s, Aldicarb severely contaminated groundwater in agricultural regions like Long Island, New York, poisoning local drinking water wells and devastating local aquatic invertebrates.
Regulatory Action: Due to the severe acute poisoning risks to workers and widespread groundwater contamination, the EPA classified it as a Restricted Use Pesticide (RUP) and eventually brokered an agreement to phase out its use in the United States entirely by 2018.
Endosulfan (Organochlorine Insecticide)
Farmworker and Community Harm: Endosulfan is an acute neurotoxin and a severe endocrine disruptor. While acute exposure causes fatal convulsions, its most devastating documented harm is chronic. The most infamous field reports originate from Kasaragod, Kerala (India), where two decades of aerial Endosulfan spraying over plantations resulted in thousands of locals and farmworkers suffering from severe congenital deformities, delayed puberty, mental disabilities, and systemic neurological collapse.
Animal & Ecosystem Harm: Endosulfan is a Persistent Organic Pollutant (POP), meaning it does not easily break down in nature and bioaccumulates in the food chain. It is exceptionally toxic to aquatic ecosystems. Agricultural runoff from cotton fields into local waterways has routinely caused catastrophic, localized fish kills and wiped out amphibian populations by destroying their central nervous systems.
Regulatory Action: The overwhelming epidemiological evidence of its catastrophic impact on rural farming communities and wildlife led to Endosulfan being globally banned under the Stockholm Convention in 2011.